96-tsime sero tsika ndiro chakuvhuvhu
96-tsime sero tsika ndiro chakuvhuvhu
Kunyatsoongorora Uinjiniya hweSainzi yeHupenyu: Ansix Unyanzvi hweTekinoroji muKuumba Mapureti eMatsime 96
Kubva paKugadzira Lab kusvika paKugadzirwa Kwakawanda: Rwendo rweChishamiso Chakajairika
Munyika ine matambudziko makuru ekutsvaga mishonga uye biotechnology, kukurumidza uye kuvimbika ndizvo zvinonyanya kukosha. Pakati pemasystem akawanda ekuongorora anonyanya kushandiswa—mashandiro ega anoedza zviuru zvevaya vanoshandisa mishonga—pane chinhu chepurasitiki chiri nyore chinonyengera: ndiro yekukura kwemasero ine 96-well. Kwemakumi emakore, iyi puratifomu yakajairika, ine nhanho yayo yekunze ye127.76 x 85.48 mm, yave iri jira repasi rose rekuyedza kwezvebhayoloji nemakemikari.
Zvisinei, kugadzira maplate aya ibasa reinjiniya rakaomarara zvinoshamisa. Zvinoda musanganiswa wakabatana wekuita nemazvo, kujeka kwemaziso, uye kugara kwakaringana kuti ive nechokwadi chekuti sero rinokura murabhoritari muBoston rinowana mamiriro akafanana neeriri muBerlin. Sezvo vatungamiriri vemaindasitiri vachikurudzira kuti madziro aite matsime 384 uye kunyange 1536, matambudziko ehunyanzvi anowedzera, zvichiita kuti ukobvu hwemadziro hudzike kusvika pa0.5 mm kana pasi. Kuna Ansix Tech, nyanzvi mukugadzira majekiseni nemazvo, kukunda matambudziko aya hakusi basa rekugadzira chete—kuzvipira kukurumidzisa kuwanikwa kwesainzi pasi rose.
Nheyo: Dhizaini uye Kugadzira Zvifananidzo Zvinotungamirirwa Nemazvo
Kugadzirwa kwemould ine matsime makumi mapfumbamwe nematanhatu kunotanga kare simbi isati yachekwa. PaAnsix Tech, maitiro acho akavakirwa muDesign for Manufacturability (DFM), dzidziso inovhara musiyano uripo pakati pekugadzira kwakanaka nekugadzira kunokwanisika uye kusingadhuri.
Kugadzira Kwekutanga uye Kutevedzera: Mainjiniya anotanga nehukuru hwakakosha hweplate: kudzika kwetsime, kutsetseka kwepasi kuti pave nemicroscope yakafanana, uye nzvimbo chaiyo ye9 mm pakati nepakati inoita kuti ienderane nemidziyo yekubata mvura inogadzirwa otomatiki. Vachishandisa software yepamusoro yekufananidzira, vanoita ongororo yekuyerera kwemould kuti vafanotaura kuti purasitiki yakanyungudutswa ichazadza sei makomba makumi mapfumbamwe nematanhatu akaomarara emould. Kuedza uku kwakakosha pakuona zvikanganiso zvinogona kuitika senge misungo yemhepo, mitsetse yeweld (inogona kunetesa chimiro), kana kuzadza kusina kuenzana kunogona kukonzera kukanganisa.
Kugadzira uye Kusimbisa: Muenzaniso chaiwo unozogadzirwa, kazhinji uchishandisa nzira dzekushandisa nekukurumidza. Danho iri harisi rekungoongorora nemaziso chete. Mainjiniya vanoita bvunzo dzakasimba dzekusimbisa: kuyera miganhu yekushivirira inowanzo chengetwa mukati me ± 0.1 mm, kutarisa kugadzikana kwenzvimbo, uye kusimbisa hunhu hwepasi peplate. Ruzivo urwu rwekuongorora rwunodzoserwa kunatsiridza modhi yedhijitari, kuve nechokwadi chekuti modhi yekupedzisira iri kushanda. Dhizaini yeFomu yakasimba.
Mwoyo weNyaya: Mould Yepamusoro Dhizaini uye Kugadzira
Nekugadzirwa kwakasimbiswa, chinangwa chinoshanduka pakugadzira mold pachayo—chishandiso chakanyatsojeka chinotsanangura kunaka kwechikamu uye hupfumi hwepurojekiti.
Kusarudzwa kweSimbi yeMould: Kusarudzwa kwesimbi kwakakosha kuti igare kwenguva refu uye ive neunyanzvi. Kune maplate ane matsime makumi mapfumbamwe nematanhatu, Ansix Tech inowanzo shandisa masteels akaomarara, anodzivirira ngura akadai seS136 kana DIN 1.2344. Zvinhu izvi zvepamusoro zvinodzivirira kupera simba kubva mumapurasitiki anokwesha uye zvinotsungirira kupisa nguva dzose kwejekiseni rekugadzira, zvichiita kuti mould ibudise makumi ezviuru emaplates asina kuora mumhando.
Kugadzira Sisitimu Yepakati: Mukati memold inyanzvi yekugadzira zvinhu zvidiki. Sisitimu yegeti—nzira dzinopinda nepurasitiki mumakomba—inofanira kugadzirwa zvine hungwaru. Masisitimu ekupisa anowanzo shandiswa kubvisa marara uye kuona kuti zvinhu zvinoyerera zvakanaka kuenda kutsime rega rega. Sisitimu yekuburitsa mvura inoshandisa mapini akawanda akaiswa nemazvo kuti isundire plate yakapfava kubva mumold zvinyoro nyoro asi zvakasimba pasina kukonzera zviratidzo zvekushushikana kana kushanduka.
Kuchinja Kwekutonhodza: Zvichida chinhu chitsva chikuru chiri mukutonhodza. Nzira dzechinyakare dzekuboorera dzakatwasuka dzinowanzo tungamira mukutonhodza kusina kuenzana, zvichikonzera kupwanyika uye kuwedzera nguva yekutenderera. Ansix Tech inoshandisa nzira dzekutonhodza dzakadhindwa mu3D. Nzira idzi, dzakagadzirwa dzichishandisa Direct Metal Laser Sintering (DMLS), dzinogona kusvetuka nekutenderera zvakakwana kutenderedza chimiro chetsime rega rega, dzichitevera chimiro chemold padaro rakafanana.
Kukanganisa: Iyi tekinoroji inogonesa kubviswa kwekupisa nekukurumidza uye kwakafanana. Nekuchengetedza tembiricha yakakwana yeforoma, inoderedza zvakanyanya nguva yekutonhodza yechikamu—chikamu chimwe chete chakareba kwazvo muchikamu chekupinza. Zvidzidzo zvemuenzaniso kubva kuindasitiri zvinoratidza kuti kutonhodza kwakadaro kunogona kuderedza nguva yekutenderera neinopfuura 25%, zvichishandura zvakananga kubuditsa kwakakwira uye mutengo wakaderera pachikamu chimwe nechimwe.
Kugona Maitiro Ekuita: Kubva paSainzi Yezvinhu Kusvika paKuvimbisa Hunhu Hwakanaka
Nekuumbwa kwakanaka, dambudziko rekupedzisira nderekuita maitiro ekuumba nejekiseni nekuenderana kwakakwana.
Sainzi Yezvinhu Inoshanda: Chinhu chinoshandiswa muindasitiri iyi ipolystyrene (PS). Kana chakachena, PS haidi mvura, asi pakumera kwemasero, maplate mazhinji anogadziriswa pamusoro (senge gas plasma) kuti aite kuti afambe zvakanaka uye akwanise kunamirwa nemasero. Ansix Tech inoshanda pamwe chete nevatengesi veresin kuti vasarudze magiredhi chaiwo ePS anopa chiyero chakanakisa chekujeka, simba, uye hunhu hwekuyerera kwemadziro matete. Zvimwe zvinogona kuiswa kune zvinodiwa chaizvo, zvakaita seruvara rutema rwekuyedza fluorescence kana magiredhi eUV-transmissive kune mamwe mashandisirwo akakosha.
Kugadzirisa Maitiro uye Kudzora: Maitiro ekuumba anotongwa nematanho akawanda akabatana: tembiricha yekunyunguduka, kumhanya kwejekiseni nekumanikidzwa, kumanikidzwa kwepakeji, uye nguva yekutonhodza. Ansix Tech inoshandisa misimboti yesainzi yekuumba uye maalgorithms ekugadzirisa zvinangwa zvakawanda kuti iwane resipi yakakwana. Aya maalgorithms anoenzanisa zvinangwa zvinokwikwidzana—kuderedza nguva yekutenderera, kuderedza kushandiswa kwezvinhu, uye kuwedzera mhando—kuti iwane setup inoshanda zvakanyanya.
Kuvimbiswa Kwemhando Yepamusoro Kusingaperi: Hunhu hahukurukurwi muzvidzidzo zvehupenyu. Kugadzirwa kwese kunoongororwa kuburikidza neStatistical Process Control (SPC), kutevedzera zviyero zvakakosha munguva chaiyo. Maplate apedzwa anoongororwa kuti aone kana paine zvikanganiso zvekuona, asiwo kuti aone kana paine hunhu hunoshanda. Kusatsetseka kwakakosha kudzivirira kufamba kwemvura pakati pematsime, uye kujeka kwemaziso kunosimbiswa. Zvakakosha kuti maplate akagadzirirwa basa rezvinhu zvipenyu zvinonzwa arongedzwe munzvimbo dzakachena kuitira kuti ave nechokwadi chekuti haana utachiona uye haana ma pyrogens kana ma DNases anogona kukanganisa kuyedza.
Kupa Kukosha: Kuzvipira kweAnsix Tech kuKubatana
Hunyanzvi hweAnsix Tech hunoshandura mabhenefiti akananga uye anooneka kune vatengi vayo muzvikamu zvekuongorora uye zvebiotech.
Kuderedza Mutengo Kuburikidza Nekushanda Kwazvo: Maitiro ekambani ekuchengetedza mari akazara. Anotanga nekuvandudza zvinhu, achivimbisa kuti hapana mainjiniya akawandisa. Anowanikwa kuburikidza nekugadzirisa maitiro kunobvisa masekonzi kubva pakutenderera kwega kwega, zvichiwedzera kubuda. Izvi zvinosimbiswa nekubudirira kwekutanga mukugadzira mold, zvichibvisa kugadzirisa mold kunodhura uye kunotora nguva. Kushanda uku kwakabatana kunobvumira Ansix Tech kuderedza zvakanyanya mutengo weyuniti yezvikamu pasina kukanganisa mwero chaiwo unodiwa neindasitiri.
Kumhanya uye Kuvimbika: Vachiziva kuti nguva yekuenda kumusika inokosha mukutsvagisa, Ansix Tech yakagadzirisa mashandiro ayo kubva pakugadzira kusvika pakuendesa. Nekuziva zvese zviri muketani uye kushandisa matekinoroji akadai sekutonhodza kwe conformal uye digital simulation, vanovimbisa kwete kungogadzira prototyping nekukurumidza asiwo kugadzirwa kwezvinhu zvinofungidzirwa, zvinokwanisa kukura, uye nekukurumidza.
Ndiro ine matsime makumi mapfumbamwe nematanhatu inoita kuti mushonga wemazuva ano uve wakanyarara. Seri kwechimiro chayo chiri nyore chepolystyrene kune nyika yeinjiniya yepamusoro, sainzi yezvinhu, uye kugadzirwa kwemazvo. Nekuziva kuoma uku, Ansix Tech inoita zvinopfuura kugadzira zvinhu zvepurasitiki zvinodyiwa; inopa hwaro hwekuvimbika uko vaongorori vanogona kuvaka kufambira mberi kunotevera, vachivimba kuti ndiro chaiyo inochengeta kuwanikwa kwavo yakagadzirwa zvakakwana.
Ansix Tech Co Ltd.
Kana muine zvirongwa zvine chekuita ne96-well cell culture plate mold, munogona kutibata chero nguva. Tichashandura pfungwa dzenyu kuita chokwadi, toita kuti zviroto zvenyu zvizadzike, uye towana maodha makuru kubva kumusika. Ruzivo rwedu rwekuonana ndi info@ansixtech.com. Kana kuti batai CTO wedu, tumirai tsamba ku: stephen@ansixtech.com
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